2009, discovery of a different phenotype for micro organism in slender nanofluidic slits; and first detection of local protein structures along DNA using solid-point out nanopores
Our group studies bacterial mobile division and is also aiming to constitute a ‘base up biology’ in artificial cells that could autonomously divide. Our principal interest lies in mobile division, chromatin framework, and spatial Management.
Again in 1991, Sumio Iijima with the NEC Company experienced described the synthesis of carbon nanotubes. Band framework calculations instructed that these nanotubes could show metallic band conduction. This may be an important gain about the conducting polymers we experienced explored, which ended up, in truth, disordered semiconductors presenting just variable-array hopping conductivity.
Our operate was speedily adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 posted their conclusions on transistors comprised of one- and multi-walled carbon nanotubes in Utilized Physics Letters.
This yielded a breakthrough. Within just only a few months, we were being capable to measure transportation via someone single-walled carbon nanotube. Depending on low-temperature experiments by an excellent PhD student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation having an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with quite long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
What distinguishes biology from chemistry is these components jointly make up a living technique. The secret of explained lifestyle, I feel, lies within the interactions, the interaction of These molecules. The large question with regards to the origin of lifestyle remains to be unanswered. How did we ever evolve from straightforward molecules in to the particularly complicated programs we see today? We don't know. I would like to operate on these kinds of massive, open up questions.’
Researching DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
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Extremely amazing, but that wasn’t really the place my desire lay. I desired to pioneer and I had the feeling which was now not feasible, since the most appealing fundamental insights had previously been uncovered. But my industry had produced quite a few exciting new resources to measure particular person molecules. I made a decision that I desired to use this to biology, to take a look at it from the Actual physical point of view.’
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
‘That considerations the artificial cell, as Section of the Dutch BaSyC initiative. Craig Venter appeared best-down in Those people days and ceesdekker.net determined about 5 hundred genes which can be minimally demanded for any operating mobile. We want to glance bottom-up: how do we go from the couple of molecules to a whole Organic system?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
The biophysicist from Delft – who has been one of the most cited experts from the Netherlands For several years – normally takes his duty to contribute to the rationalization and popularisation of his get the job done with the border of physics and biology incredibly critically and regularly seems while in the media; if not to talk about his get the job done, then about the relationship in between science and his Christian religion.